The first 3 rounds are just for points to get into the last 16 (or 8 if not 16 teams), with only the top 4 players scoring from each team. So missing a game in the first 3 is not too bad, I would expect that not all teams will have all 6 players playing every week although having 6 would be an advantage. When we get to the knockout stage, having a player missing then would put us at a disadvantage.